9BOE

Crystal Structure of E166V SARS-CoV-2 Main Protease in Complex with GC376

Summary for 9BOE

• Entry DOI: 10.2210/pdb9boe/pdb
• Related PRD ID: PRD_002495
• Descriptor: 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide (3 entities in total)
• Functional Keywords: hydrolase, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 2
• Total formula weight: 68402.10

Authors

Papini, C.,Kenneson, J.,Anderson, K.S. (deposition date: 2024-05-03, release date: 2025-02-12)

• Primary citation: Kenneson, J.R.,Papini, C.,Tang, S.,Huynh, K.,Zhang, C.H.,Jorgensen, W.L.,Anderson, K.S.; Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (Mpro) with Noncovalent Preclinical Candidate, Mpro61; Acs Bio Med Chem Au, 2025; DOI: 10.1021/acsbiomedchemau.4c00109

Experimental method

X-RAY DIFFRACTION (2.02 Å)