9BKM

DHODH in complex with Ligand 10

これはPDB形式変換不可エントリーです。

9BKM の概要

• エントリーDOI: 10.2210/pdb9bkm/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total)
• 機能のキーワード: dihydroorotate dehydrogenase, dhodh, oxidoreductase, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41496.32

構造登録者

Shaffer, P.L. (登録日: 2024-04-29, 公開日: 2024-07-03)

• 主引用文献: DeRatt, L.G.,Zhang, Z.,Pietsch, C.,Cisar, J.S.,Zhang, X.,Wang, W.,Tanner, A.,Matico, R.,Shaffer, P.,Jacoby, E.,Kazmi, F.,Shukla, N.,Bush, T.L.,Patrick, A.,Philippar, U.,Attar, R.,Edwards, J.P.,Kuduk, S.D.; Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.; J.Med.Chem., 2024; PubMed: 38889244; DOI: 10.1021/acs.jmedchem.4c00809

実験手法

X-RAY DIFFRACTION (2.08 Å)