9BJM

Crystal Structure of Inhibitor 5c in Complex with Prefusion RSV F Glycoprotein

This is a non-PDB format compatible entry.

Summary for 9BJM

• Entry DOI: 10.2210/pdb9bjm/pdb
• Descriptor: Prefusion RSV F (DS-CAV1),Envelope glycoprotein, 1'-{[5-chloro-1-(4,4,4-trifluorobutyl)-1H-1,3-benzimidazol-2-yl]methyl}-1-(methanesulfonyl)spiro[azetidine-3,3'-indol]-2'(1'H)-one (3 entities in total)
• Functional Keywords: inhibitor, viral protein, complex, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: human respiratory syncytial virus; More
• Total number of polymer chains: 1
• Total formula weight: 63745.30

Authors

Shaffer, P.L.,Milligan, C.,Abeywickrema, P. (deposition date: 2024-04-25, release date: 2024-07-10)

• Primary citation: Kesteleyn, B.,Herschke, F.,Darville, N.,Stoops, B.,Jacobs, T.,Jacoby, E.,Shaffer, P.,Lammens, L.,Van Rompaey, D.,Matcha, K.,Martinez Lamenca, C.,Coesemans, E.,Hache, G.,Pieters, S.,Lecomte, M.,Hu, L.,Demin, S.,Milligan, C.,Abeywickrema, P.,De Bruyn, S.,Van Den Berg, J.,Ysebaert, N.,De Zwart, L.,Najera, I.,Rigaux, P.,Roymans, D.,Jonckers, T.H.M.; Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections.; J.Med.Chem., 2024; PubMed: 38932487; DOI: 10.1021/acs.jmedchem.4c00514

Experimental method

X-RAY DIFFRACTION (2.07 Å)