9BJJ

Cryo-EM structure of NVL bound the the MM017 inhibitor

Summary for 9BJJ

Entry DOI	10.2210/pdb9bjj/pdb
EMDB information	44634
Descriptor	Nuclear valosin-containing protein-like, Peptide substrate mimic, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	ribosome biogenesis, aaa+ atpase, translocase
Biological source	Homo sapiens (human) More
Total number of polymer chains	7
Total formula weight	579973.45
Authors	Cruz, V.E.,Erzberger, J.P. (deposition date: 2024-04-25, release date: 2026-01-21)
Primary citation	Guo, H.H.,Tao, Y.,Cruz, V.E.,Fang, M.,Khivansara, V.,Xie, S.,Leach, A.,Rivera-Cancel, G.,Barrows, N.,Williams, N.,Aurora, A.,Erzberger, J.P.,De Brabander, J.K.,Nijhawan, D. Dibenzothiazepinones are bioavailable inhibitors of NVL and cause p53-dependent apoptosis in cancer by blocking 60S ribosome assembly To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.06 Å)

Structure validation