9BJC

Crystal structure of CDK2/Cyclin E1 in complex with XC208

This is a non-PDB format compatible entry.

Summary for 9BJC

• Entry DOI: 10.2210/pdb9bjc/pdb
• Related: 9BJB 9BJD
• Descriptor: Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, (5aS,6S,7S)-3,7-dihydroxy-6-methoxy-1,4,6,9-tetramethyl-6,7-dihydrodibenzo[b,f][1,4]oxazepine-8,11(5aH,10H)-dione, ... (4 entities in total)
• Functional Keywords: cyclin-dependent kinase 2 g1/s-specific cyclin-e1 inhibitor, cell cycle, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 67487.36

Authors

Hosford, C.J.,Yano, J.,Thevakumaran, N.,Davison, J.,Romeril, S.,Choi, Y.,Hadjithomas, M.,Verdine, G.L. (deposition date: 2024-04-25, release date: 2025-08-27)

• Primary citation: Verdine, G.L.; Nature-guided discovery of a tunable kinase inhibitor scaffold; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.22 Å)