9BHI
Crystal structure of the MerTK kinase domain with SA4488
This is a non-PDB format compatible entry.
Summary for 9BHI
Entry DOI | 10.2210/pdb9bhi/pdb |
Descriptor | Mer tyrosine kinase domain, (5P)-2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-{(1R,2S)-2-[(4'-{2-[4-(2-oxoethyl)piperazin-1-yl]propan-2-yl}[1,1'-biphenyl]-4-yl)methoxy]cyclopentyl}pyridine-3-carboxamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | receptor tyrosine kinase, atp competitive inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38113.72 |
Authors | |
Primary citation | Yu, Y.,Jang, M.,Miyashiro, J.,Clark, R.F.,Zhu, G.D.,Gong, J.,Dai, Y.,Frey, R.R.,Penning, T.D.,Kim, H.,Lee, H.K.,Kim, J.K.,Ryu, K.M.,Park, S.J.,Yoon, T.,Li, T.,Kurnick, M.D.,Kapecki, N.J.,Li, L.,Gorman, J.V.,Montgomery, D.A.,Manaves, V.,Bromberg, K.D.,Doktor, S.Z.,Thakur, A.,Wang, J.,Smith, H.A.,Buchanan, F.G.,Ferguson, D.C.,Torrent, M.,Jakob, C.G.,Qiu, W.,Upadhyay, A.K.,Martin, R.L.,Lai, A.,Michaelides, M.R. Discovery of A-910, a Highly Potent and Orally Bioavailable Dual MerTK/Axl-Selective Tyrosine Kinase Inhibitor. J.Med.Chem., 2024 Cited by PubMed: 39283694DOI: 10.1021/acs.jmedchem.4c01450 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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