9BEW

Cryo-EM structure of the HIV-1 BG505 IDL Env trimer in complex with 3BNC117 and 10-1074 Fabs

This is a non-PDB format compatible entry.

Summary for 9BEW

• Entry DOI: 10.2210/pdb9bew/pdb
• EMDB information: 44482 44484 44491
• Descriptor: Envelope glycoprotein gp120, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• Functional Keywords: cd4, hiv-1, sosip, vaccine, gp120, gp41, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Total number of polymer chains: 18
• Total formula weight: 528828.41

Authors

Gorman, J.,Kwong, P.D. (deposition date: 2024-04-16, release date: 2024-07-31)

• Primary citation: Zhang, P.,Gorman, J.,Tsybovsky, Y.,Lu, M.,Liu, Q.,Gopan, V.,Singh, M.,Lin, Y.,Miao, H.,Seo, Y.,Kwon, A.,Olia, A.S.,Chuang, G.Y.,Geng, H.,Lai, Y.T.,Zhou, T.,Mascola, J.R.,Mothes, W.,Kwong, P.D.,Lusso, P.; Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation.; Cell Rep, 43:114518-114518, 2024; PubMed: 39028623; DOI: 10.1016/j.celrep.2024.114518

Experimental method

ELECTRON MICROSCOPY (3.3 Å)