9BDR

Cryo-EM structure of cardiac amyloid fibril from a variant ATTRV122delta, double filament morphology 1

Summary for 9BDR

Entry DOI	10.2210/pdb9bdr/pdb
EMDB information	44466
Descriptor	Transthyretin (1 entity in total)
Functional Keywords	attr, transthyretin amyloidosis, v122delta, ex vivo, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	10
Total formula weight	136782.29
Authors	Nguyen, B.A.,Ahmed, Y.,Saelices, L. (deposition date: 2024-04-12, release date: 2025-10-15, Last modification date: 2026-04-29)
Primary citation	Ahmed, Y.,Nguyen, B.A.,Kelly, C.,Afrin, S.,Singh, V.,Evers, B.M.,Shelton, J.M.,Lopez Escobar, C.,Singh, P.,Pedretti, R.,Wang, L.,Bassett, P.,Fernandez-Ramirez, M.D.C.,Pekala, M.,Lemoff, A.,Kluve-Beckerman, B.,Saelices, L. Amyloid fibril polymorphism in the heart and liver of a patient with polyneuropathic ATTRv-V122 Delta amyloidosis Commun Biol, 2026 Cited by DOI: 10.1038/s42003-026-09919-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.82 Å)

Structure validation