9BDM

Cryo-EM structure of cardiac amyloid fibril from a variant ATTRV122delta, single filament morphology

Summary for 9BDM

Entry DOI	10.2210/pdb9bdm/pdb
EMDB information	44462
Descriptor	Transthyretin (1 entity in total)
Functional Keywords	attr, systemic amyloidosis, v122delta, amyloid, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	5
Total formula weight	68391.14
Authors	Nguyen, B.A.,Ahmed, Y.,Saelices, L. (deposition date: 2024-04-12, release date: 2025-10-15, Last modification date: 2026-04-29)
Primary citation	Ahmed, Y.,Nguyen, B.A.,Kelly, C.,Afrin, S.,Singh, V.,Evers, B.M.,Shelton, J.M.,Lopez Escobar, C.,Singh, P.,Pedretti, R.,Wang, L.,Bassett, P.,Fernandez-Ramirez, M.D.C.,Pekala, M.,Lemoff, A.,Kluve-Beckerman, B.,Saelices, L. Amyloid fibril polymorphism in the heart and liver of a patient with polyneuropathic ATTRv-V122 Delta amyloidosis Commun Biol, 2026 Cited by DOI: 10.1038/s42003-026-09919-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.63 Å)

Structure validation