9B9Y
Structural mechanism of CB1R binding to peripheral and biased inverse agonists
Summary for 9B9Y
Entry DOI | 10.2210/pdb9b9y/pdb |
EMDB information | 44392 |
Descriptor | Cannabinoid receptor 1,Glycogen synthase, CNb36, N-[(2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (3 entities in total) |
Functional Keywords | obesity, membrane protein, nanobody, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 75305.57 |
Authors | Kumari, P.,Dvoracsko, S.,Enos, M.D.,Ramesh, K.,Lim, D.,Hassan, S.A.,Kunos, G.,Iyer, M.R.,Rosenbaum, D.M. (deposition date: 2024-04-03, release date: 2024-11-20, Last modification date: 2024-11-27) |
Primary citation | Kumari, P.,Dvoracsko, S.,Enos, M.D.,Ramesh, K.,Lim, D.,Hassan, S.A.,Kunos, G.,Iyer, M.R.,Rosenbaum, D.M. Structural mechanism of CB1R binding to peripheral and biased inverse agonists To Be Published, |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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