9B6I

Cryo-EM structure of the avian great tit TRPM8 channel in complex with the antagonist TC-I 2014

Summary for 9B6I

Entry DOI	10.2210/pdb9b6i/pdb
EMDB information	44260
Descriptor	Transient receptor potential cation channel subfamily M member 8, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... (4 entities in total)
Functional Keywords	trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, trpm8 activation, trpm8 inhibition, trpm8 desensitization, trpm8 antagonists, membrane protein
Biological source	Parus major (Great Tit)
Total number of polymer chains	4
Total formula weight	537682.37
Authors	Yin, Y.,Park, C.-G.,Zhang, F.,Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.-Y. (deposition date: 2024-03-25, release date: 2024-08-21)
Primary citation	Yin, Y.,Park, C.G.,Zhang, F.,G Fedor, J.,Feng, S.,Suo, Y.,Im, W.,Lee, S.Y. Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. Sci Adv, 10:eadp2211-eadp2211, 2024 Cited by PubMed: 39093967 DOI: 10.1126/sciadv.adp2211 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.26 Å)

Structure validation