9B33

Structure of concanavalin A (ConA) dimer from the open-state structure of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one ConA dimer. Type II interface between GluK2 ligand-binding domain and ConA

9B33 の概要

• エントリーDOI: 10.2210/pdb9b33/pdb
• EMDBエントリー: 44124
• 分子名称: Concanavalin V, ZINC ION, CALCIUM ION (3 entities in total)
• 機能のキーワード: kainate receptor, gluk2, positive allosteric modulator, bpam344, open, concanavalin a, cona, glutamate, membrane protein
• 由来する生物種: Canavalia ensiformis (jack bean)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51455.74

構造登録者

Nadezhdin, K.D.,Gangwar, S.P.,Sobolevsky, A.I. (登録日: 2024-03-18, 公開日: 2024-05-22, 最終更新日: 2024-06-26)

• 主引用文献: Gangwar, S.P.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Yen, L.Y.,Newton, T.P.,Aktolun, M.,Kurnikova, M.G.,Sobolevsky, A.I.; Kainate receptor channel opening and gating mechanism.; Nature, 630:762-768, 2024; PubMed: 38778115; DOI: 10.1038/s41586-024-07475-0

実験手法

ELECTRON MICROSCOPY (4.07 Å)