9B1Q

Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PYN1 inhibitor

This is a non-PDB format compatible entry.

Summary for 9B1Q

• Entry DOI: 10.2210/pdb9b1q/pdb
• Related: 8VTQ 8VUG 8W1H 8W2K 9AT2 9B17
• Descriptor: Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, (5P)-1-[(imidazolidin-1-yl)methyl]-5-(1H-indol-3-yl)-1H-1,2,3-benzotriazole, ... (5 entities in total)
• Functional Keywords: inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 185342.60

Authors

Geeraerts, Z.,Yeh, S.-R. (deposition date: 2024-03-13, release date: 2024-08-21, Last modification date: 2024-09-11)

• Primary citation: Geeraerts, Z.,Ishigami, I.,Lewis-Ballester, A.,Pham, K.N.,Kozlova, A.,Mathieu, C.,Frederick, R.,Yeh, S.R.; Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.; J.Med.Chem., 67:14543-14552, 2024; PubMed: 39106326; DOI: 10.1021/acs.jmedchem.4c01360

Experimental method

X-RAY DIFFRACTION (2.624 Å)