9AZU

Crystal structure of PDC-3 beta-lactamase in complex with taniborbactam

Summary for 9AZU

• Entry DOI: 10.2210/pdb9azu/pdb
• Descriptor: Beta-lactamase, (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid (3 entities in total)
• Functional Keywords: beta-lactamase, boronic acid inhibitor, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 43808.45

Authors

Kumar, V.,van den Akker, F. (deposition date: 2024-03-11, release date: 2025-03-19)

• Primary citation: Mack, A.R.,Kumar, V.,Bethel, C.R.,Taracila, M.A.,Miller, B.A.,Six, D.A.,Uehara, T.,Papp-Wallace, K.M.,van den Akker, F.,Bonomo, R.A.; Mechanisms of Antibiotic Resistance and Inhibition of PDC-88, a Cefepime-Hydrolyzing R2-loop Deletion Variant of Pseudomonas-derived Cephalosporinase; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.73 Å)