9AYL

Cryo-EM structure of human Cav3.2 with ACT-709478

This is a non-PDB format compatible entry.

Summary for 9AYL

• Entry DOI: 10.2210/pdb9ayl/pdb
• EMDB information: 43995
• Descriptor: Voltage-dependent T-type calcium channel subunit alpha-1H, N-{1-[(5-cyanopyridin-2-yl)methyl]-1H-pyrazol-3-yl}-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: cav3.2, voltage gated calcium channel, cryo-em, transport protein, act-709478
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 240874.75

Authors

Fan, X.,Huang, J.,Yan, N. (deposition date: 2024-03-08, release date: 2024-04-24, Last modification date: 2024-06-12)

• Primary citation: Huang, J.,Fan, X.,Jin, X.,Lyu, C.,Guo, Q.,Liu, T.,Chen, J.,Davakan, A.,Lory, P.,Yan, N.; Structural basis for human Ca v 3.2 inhibition by selective antagonists.; Cell Res., 34:440-450, 2024; PubMed: 38605177; DOI: 10.1038/s41422-024-00959-8

Experimental method

ELECTRON MICROSCOPY (2.8 Å)