9AXM
Crystal structure of ARAF/MEK1 complex with NST-628 and a RAF dimer
This is a non-PDB format compatible entry.
Summary for 9AXM
Entry DOI | 10.2210/pdb9axm/pdb |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, Serine/threonine-protein kinase A-Raf, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... (8 entities in total) |
Functional Keywords | inhibitor, complex, signaling protein, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 134909.10 |
Authors | |
Primary citation | Ryan, M.B.,Quade, B.,Schenk, N.,Fang, Z.,Zingg, M.,Cohen, S.E.,Swalm, B.M.,Li, C.,Ozen, A.,Ye, C.,Ritorto, M.S.,Huang, X.,Dar, A.C.,Han, Y.,Hoeflich, K.P.,Hale, M.,Hagel, M. The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers. Cancer Discov, 2024 Cited by PubMed: 38588399DOI: 10.1158/2159-8290.CD-24-0139 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
Download full validation report