9AXM

Crystal structure of ARAF/MEK1 complex with NST-628 and a RAF dimer

これはPDB形式変換不可エントリーです。

9AXM の概要

• エントリーDOI: 10.2210/pdb9axm/pdb
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Serine/threonine-protein kinase A-Raf, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... (8 entities in total)
• 機能のキーワード: inhibitor, complex, signaling protein, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 134909.10

構造登録者

Quade, B.,Huang, X. (登録日: 2024-03-06, 公開日: 2024-04-17)

• 主引用文献: Ryan, M.B.,Quade, B.,Schenk, N.,Fang, Z.,Zingg, M.,Cohen, S.E.,Swalm, B.M.,Li, C.,Ozen, A.,Ye, C.,Ritorto, M.S.,Huang, X.,Dar, A.C.,Han, Y.,Hoeflich, K.P.,Hale, M.,Hagel, M.; The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers.; Cancer Discov, 2024; PubMed: 38588399; DOI: 10.1158/2159-8290.CD-24-0139

実験手法

X-RAY DIFFRACTION (2.42 Å)