9AVS

Human alpha-galactosidase A in complex with saposin B

Summary for 9AVS

• Entry DOI: 10.2210/pdb9avs/pdb
• Related: 9AXG
• Descriptor: Alpha-galactosidase A, Saposin-B, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: galactosidase, gla, saposin, sapb, fabry disease, lysosomal, hydrolase, activator protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 108503.51

Authors

Sawyer, T.K.,Garman, S.C. (deposition date: 2024-03-04, release date: 2024-04-17, Last modification date: 2024-04-24)

• Primary citation: Sawyer, T.K.,Aral, E.,Staros, J.V.,Bobst, C.E.,Garman, S.C.; Human Saposin B Ligand Binding and Presentation to alpha-Galactosidase A.; Biorxiv, 2024; PubMed: 38617236; DOI: 10.1101/2024.04.04.584535

Experimental method

X-RAY DIFFRACTION (3.53 Å)