9AVS
Human alpha-galactosidase A in complex with saposin B
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Alpha-galactosidase A | polymer | 414 | 47344.5 | 2 | UniProt (P06280) Pfam (PF16499) Pfam (PF17450) In PDB | Homo sapiens (human) | Alpha-D-galactosidase A,Alpha-D-galactoside galactohydrolase,Galactosylgalactosylglucosylceramidase GLA,Melibiase |
2 | C | Saposin-B | polymer | 82 | 9097.5 | 1 | UniProt (P07602) Pfam (PF03489) In PDB | Homo sapiens (human) | Cerebroside sulfate activator,CSAct,Dispersin,Sphingolipid activator protein 1,SAP-1,Sulfatide/GM1 activator |
3 | E | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G42466VF) | |||
4 | D, G | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
5 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
6 | H | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
7 | A, B | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
8 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
9 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, B: 32 - 429 (UniProt: P06280)
C: 1 - 79 (UniProt: P07602)
PDB | External Database | Details |
---|---|---|
Ala 170 | Asp 170 | engineered mutation |
Asp 430 | - | expression tag |
Tyr 431 | - | expression tag |
Lys 432 | - | expression tag |
Asp 433 | - | expression tag |
Asp 434 | - | expression tag |
Asp 435 | - | expression tag |
Asp 436 | - | expression tag |
Lys 437 | - | expression tag |
Asp 438 | - | expression tag |
Tyr 439 | - | expression tag |
Lys 440 | - | expression tag |
Asp 441 | - | expression tag |
Asp 442 | - | expression tag |
Asp 443 | - | expression tag |
Asp 444 | - | expression tag |
Lys 445 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 103786.4 | |
Branched | Number of molecules | 5 |
Total formula weight | 3727.4 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 989.7 | |
All* | Total formula weight | 108503.5 |