9AVN

Crystal Structure of CARD9 coiled-coil K156-K214 bound to Compound 1

Summary for 9AVN

Entry DOI	10.2210/pdb9avn/pdb
Descriptor	Caspase recruitment domain-containing protein 9, (2P)-2-(1-benzyl-3-phenyl-1H-pyrazol-4-yl)-5-chloro-1-[(1R)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]-1H-1,3-benzimidazole-6-carboxylic acid (3 entities in total)
Functional Keywords	adapter protein, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	8
Total formula weight	58277.15
Authors	Raymond, D.D.,Lemke, C.T. (deposition date: 2024-03-04, release date: 2025-03-12)
Primary citation	Raymond, D.D. Human genetics guides the discovery of novel CARD9 inhibitors with anti-inflammatory activity in vitro as well as in vivo To be published,
Experimental method	X-RAY DIFFRACTION (2.726 Å)

Structure validation