9ZXM

DDB1 delta with compound 6

This is a non-PDB format compatible entry.

Summary for 9ZXM

• Entry DOI: 10.2210/pdb9zxm/pdb
• Descriptor: DNA damage-binding protein 1, (3S,5S)-1-{(4P)-4-(2,2-difluoro-2H-1,3-benzodioxol-4-yl)-3-[(propan-2-yl)oxy]benzene-1-carbonyl}-N-methyl-5-phenylpiperidine-3-carboxamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: e3 ligase, dna-encoded library, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 96586.54

Authors

Digianantonio, K.M.,Karim, M.F.,Bekes, M. (deposition date: 2026-01-05, release date: 2026-04-08)

• Primary citation: Reddy Guduru, S.K.,Caldwell, J.P.,Digianantonio, K.M.,Prophet, S.M.,Yang, S.,Gareiss, P.,Jones, C.,Harbin, A.,Driscoll, B.,Karim, M.F.,Scott, A.,Patel, A.,Chapman, A.E.,Crandall, M.,Miklossy, G.,Barczak, N.T.,Stroppa, A.P.,Corradi, J.P.,Clark, J.J.,Chung, M.K.,Reinhardt, N.R.,Butcher, W.E.,Wilson, R.,Stiff, C.,Fathizadeh, A.,Yuan, L.,Wang, G.,Dong, H.,Beno, B.R.,Zimmermann, K.,Langley, D.R.,Cacace, A.M.,Bekes, M.; DNA-Encoded Library (DEL) Selection Identifies a Distinct DDB1 Ligand Binding Site; Acs Med.Chem.Lett., 2026; DOI: 10.1021/acsmedchemlett.6c00003

Experimental method

X-RAY DIFFRACTION (2.195 Å)