9ZN8

Structure of rabbit RyR1 complexed with FKBP12.6 and calmodulin in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions)

This is a non-PDB format compatible entry.

Summary for 9ZN8

• Entry DOI: 10.2210/pdb9zn8/pdb
• EMDB information: 74438
• Descriptor: Calmodulin-1, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... (6 entities in total)
• Functional Keywords: sarcoplasmic reticulum, intracellular calcium channel, excitation-contraction coupling, complex, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 2379755.82

Authors

Kim, K.,Clarke, O.B. (deposition date: 2025-12-12, release date: 2026-09-16)

• Primary citation: Kim, K.,Li, H.,Yuan, Q.,Melville, Z.,Zalk, R.,des Georges, A.,Frank, J.,Hendrickson, W.A.,Marks, A.R.,Clarke, O.B.; Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene; Nat Commun, 2026; DOI: 10.1038/s41467-026-76519-y

Experimental method

ELECTRON MICROSCOPY (2.57 Å)