9YKR

Crystal structure of the GLP (EHMT1) SET domain in complex with SAM and TNG917

This is a non-PDB format compatible entry.

Summary for 9YKR

• Entry DOI: 10.2210/pdb9ykr/pdb
• Descriptor: Histone-lysine N-methyltransferase EHMT1, ZINC ION, S-ADENOSYLMETHIONINE, ... (8 entities in total)
• Functional Keywords: methyltransferase, sam, histone, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65902.79

Authors

Whittington, D.A. (deposition date: 2025-10-07, release date: 2026-05-13)

• Primary citation: Lu, A.,Haines, B.B.,Zhang, W.,Zhang, M.,Whittington, D.A.,Ji, L.,Teng, T.,Ferdinez, M.L.D.,Yu, Y.,Zhang, H.,Gu, L.,Tsai, A.W.,Sudsakorn, S.,Mallender, W.D.,Williams, B.,Come, J.H.,Throner, S.,Vacca, J.,Huang, A.,Min, C.,Maxwell, J.P.,Andersen, J.N.,Chen, Y.P.; TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Anti-Tumor Immunity and Immunotherapy Efficacy; Cancer Res., 2026

Experimental method

X-RAY DIFFRACTION (1.38 Å)