9YKR
Crystal structure of the GLP (EHMT1) SET domain in complex with SAM and TNG917
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase EHMT1 | polymer | 262 | 30289.4 | 2 | UniProt (Q9H9B1) Pfam (PF05033) Pfam (PF00856) | Homo sapiens (human) | Euchromatic histone-lysine N-methyltransferase 1,Eu-HMTase1,G9a-like protein 1,GLP,GLP1,Histone H3-K9 methyltransferase 5,H3-K9-HMTase 5,Lysine N-methyltransferase 1D |
| 2 | C, D, DA, E, EA... (A, B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) PubChem (32051) | |||
| 3 | G, HA (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 4 | H, IA (A, B) | N~2~-[(7M)-6-fluoro-7-(2,5,6,7-tetrahydro-1H-azepin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]-N~4~,6-dimethylpyrimidine-2,4-diamine | non-polymer | 369.4 | 2 | Chemie (A1CXM) PubChem (168224398) | |||
| 5 | I, JA, KA, LA (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) PubChem (8117) | |||
| 6 | J, K, L, M, MA... (A, B) | SULFATE ION | non-polymer | 96.1 | 16 | Chemie (SO4) | |||
| 7 | AA, AB, BA, BB, CA... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 21 | Chemie (EDO) | |||
| 8 | DB, EB (A, B) | water | water | 18.0 | 874 | Chemie (HOH) |
Sequence modifications
A, B: 1006 - 1266 (UniProt: Q9H9B1)
| PDB | External Database | Details |
|---|---|---|
| Gly 1005 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60578.9 | |
| Non-Polymers* | Number of molecules | 53 |
| Total formula weight | 5323.9 | |
| All* | Total formula weight | 65902.8 |
