9YC4

Covalent stabilizer of the interaction between 14-3-3 sigma and Estrogen receptor-alpha peptide

This is a non-PDB format compatible entry.

Summary for 9YC4

• Entry DOI: 10.2210/pdb9yc4/pdb
• Descriptor: 14-3-3 protein sigma, Estrogen receptor Alpha Peptide, (2R)-1-[(3R,5S)-4-(chloroacetyl)-3,5-dimethylpiperazin-1-yl]-2-(4-chlorophenyl)-2-[1-(1-methyl-1H-pyrazole-4-carbonyl)piperidin-4-yl]ethan-1-one, ... (4 entities in total)
• Functional Keywords: 14-3-3, adapter, phosphoserine, phosphothreonine, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 60172.79

Authors

Knapp, M.S.,Tang, J.Y. (deposition date: 2025-09-18, release date: 2026-09-02)

• Primary citation: Jain, R.,Knapp, M.,Kochanek, S.E.,Lewis, A.,McGregor, L.M.,Stojkovic, V.,Tang, J.,Tsang, T.,Yan, K.,Yifru, A.,Zhu, Q.,Fabbiani, F.,Feng, G.,Frank, A.O.,Fuller, J.,Jahnke, W.,Jansen, J.M.,Jo, J.,Li, M.,Lipps, J.,Lu, Y.,Mladenovic, T.,Piechon, P.,Rogemoser, P.,Wang, F.,Yang, S.,Skepper, C.K.; Covalent Stabilizers of the Interaction Between 14-3-3 sigma; Acs Med.Chem.Lett., 2026; DOI: 10.1021/acsmedchemlett.6c00325

Experimental method

X-RAY DIFFRACTION (2.152 Å)