9YC4
Covalent stabilizer of the interaction between 14-3-3 sigma and Estrogen receptor-alpha peptide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | 14-3-3 protein sigma | polymer | 248 | 27807.1 | 2 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | C, D (X, Y) | Estrogen receptor Alpha Peptide | polymer | 15 | 1744.9 | 2 | UniProt (P03372) Pfam (PF12743) | Homo sapiens | |
| 3 | E, F (A, C) | (2R)-1-[(3R,5S)-4-(chloroacetyl)-3,5-dimethylpiperazin-1-yl]-2-(4-chlorophenyl)-2-[1-(1-methyl-1H-pyrazole-4-carbonyl)piperidin-4-yl]ethan-1-one | non-polymer | 534.5 | 2 | Chemie (A1CT3) | |||
| 4 | G, H, I, J (A, C, X, Y) | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
X, Y: 581 - 595 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Phe 587 | Glu 587 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 59103.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1069.0 | |
| All* | Total formula weight | 60172.8 |
