9Y7U

Crystal structure of Candida auris dihydrofolate reductase in complex with inhibitor 1282 and NADPH

Summary for 9Y7U

Entry DOI	10.2210/pdb9y7u/pdb
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-{7-[(2S)-4-(2,4-diaminopyrimidin-5-yl)but-3-yn-2-yl]-2H-1,3-benzodioxol-5-yl}-2,6-difluorophenol, ... (6 entities in total)
Functional Keywords	dihydrofolate reductase candida auris inhibitor complex, oxidoreductase
Biological source	Candidozyma auris
Total number of polymer chains	2
Total formula weight	49896.13
Authors	Erlandsen, H.,Krucinska, J.,Wright, D. (deposition date: 2025-09-11, release date: 2026-07-22)
Primary citation	Erlandsen, H.,Krucinska, J.,Wright, D. Structural and biological evaluation of non-classical antifolates as antifungal drug candidates targeting Candia auris dihydrofolate reductase. To Be Published,
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation