9VJJ

Crystal Structure of human Latent TGF-beta1 in complex with SOF10

Summary for 9VJJ

• Entry DOI: 10.2210/pdb9vjj/pdb
• Descriptor: Transforming growth factor beta-1 proprotein, SOF10 Fab heavy chain, SOF10 Fab light chain, ... (5 entities in total)
• Functional Keywords: latent tgf-beta1, cytokine, fab, antibody, fibrosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 181874.15

Authors

Kawauchi, H.,Kanamori, M.,Sato, I.,Fukami, T.A.,Irie, M.,Torizawa, T.,Shimada, H. (deposition date: 2025-06-20, release date: 2026-02-04, Last modification date: 2026-03-18)

Primary citation

Kanamori, M.,Sato, I.,Koo, C.X.,Sun, Y.,Kawauchi, H.,Nakagawa, K.,Murai, A.,Asanuma, K.,Gan, S.W.,Pang, C.L.,Shimizu, Y.,Shida-Kawazoe, M.,Kanamaru, C.,Kayukawa, Y.,Hada, N.,Ohmine, K.,Kitazawa, T.,Nezu, J.,Igawa, T.,Shimada, H.
Selective blockade of latent TGF-beta 1 activation suppresses tissue fibrosis with good safety.
Commun Med (Lond), 6:-, 2026

PubMed Abstract: Fibrosis is a hallmark of organ failure observed after chronic epithelial injury and inflammation. The transforming growth factor beta (TGF-β) is the master regulator of fibrogenesis, so blockade of the TGF-β pathway is a potential treatment strategy for fibrosis; however, the therapeutic potential of pan-TGF-β blockade is limited by side effects.

PubMed: 41606188
DOI: 10.1038/s43856-026-01408-w

Experimental method

X-RAY DIFFRACTION (2.477 Å)