9VJJ
Crystal Structure of human Latent TGF-beta1 in complex with SOF10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transforming growth factor beta-1 proprotein | polymer | 369 | 42304.1 | 2 | UniProt (P01137) Pfam (PF00688) Pfam (PF00019) | Homo sapiens (human) | |
| 2 | C, D (H, I) | SOF10 Fab heavy chain | polymer | 227 | 24512.5 | 2 | Homo sapiens | ||
| 3 | E, F (L, M) | SOF10 Fab light chain | polymer | 215 | 23271.6 | 2 | Homo sapiens | ||
| 4 | G, H, I, J (X, C, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 5 | K, L, M (B, L, M) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B: 30 - 390 (UniProt: P01137)
| PDB | External Database | Details |
|---|---|---|
| Asp 22 | - | expression tag |
| Tyr 23 | - | expression tag |
| Lys 24 | - | expression tag |
| Asp 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Asp 27 | - | expression tag |
| Asp 28 | - | expression tag |
| Lys 29 | - | expression tag |
| Ser 33 | Cys 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 180176.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| All* | Total formula weight | 181874.2 |
