9UNV

Cryo-EM structure of human organic solute transporter Ost-alpha/beta bound with TLCA

This is a non-PDB format compatible entry.

Summary for 9UNV

• Entry DOI: 10.2210/pdb9unv/pdb
• EMDB information: 64364
• Descriptor: Organic solute transporter subunit alpha, Organic solute transporter subunit beta, CHOLESTEROL, ... (9 entities in total)
• Functional Keywords: complex, bile acids, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 130298.17

Authors

Yang, X.,Xu, E. (deposition date: 2025-04-24, release date: 2025-12-10, Last modification date: 2026-02-04)

• Primary citation: Yang, X.,Cui, N.,Li, T.,He, X.,Zhang, H.,Wu, C.,Li, Y.,Ma, X.,Xu, E.; Structures of Ostalpha/beta reveal a unique fold and bile acid transport mechanism; Nature, 2026; DOI: 10.1038/s41586-025-10029-7

Experimental method

ELECTRON MICROSCOPY (3.12 Å)