9UNV

Cryo-EM structure of human organic solute transporter Ost-alpha/beta bound with TLCA

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0032782	biological_process	bile acid secretion
A	0032991	cellular_component	protein-containing complex
A	0042803	molecular_function	protein homodimerization activity
A	0046982	molecular_function	protein heterodimerization activity
A	0055085	biological_process	transmembrane transport
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0032782	biological_process	bile acid secretion
B	0032991	cellular_component	protein-containing complex
B	0046982	molecular_function	protein heterodimerization activity
B	0055085	biological_process	transmembrane transport
C	0005515	molecular_function	protein binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0015125	molecular_function	bile acid transmembrane transporter activity
C	0015721	biological_process	bile acid and bile salt transport
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0032782	biological_process	bile acid secretion
C	0032991	cellular_component	protein-containing complex
C	0042803	molecular_function	protein homodimerization activity
C	0046982	molecular_function	protein heterodimerization activity
C	0055085	biological_process	transmembrane transport
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0015125	molecular_function	bile acid transmembrane transporter activity
D	0015721	biological_process	bile acid and bile salt transport
D	0016020	cellular_component	membrane
D	0016323	cellular_component	basolateral plasma membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0032782	biological_process	bile acid secretion
D	0032991	cellular_component	protein-containing complex
D	0046982	molecular_function	protein heterodimerization activity
D	0055085	biological_process	transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	70
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	58
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	58
Details	Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	58
Details	Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	28
Details	Region: {"description":"Extracellular loop 1 (ECL1)","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	28
Details	Region: {"description":"Extracellular loop 2 (ECL2)","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	18
Details	Motif: {"description":"Cysteine-rich loop","evidences":[{"source":"PubMed","id":"41606314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"41606314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"41606314","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	6
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"41606314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"41606314","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9LJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=TM0","evidences":[{"source":"PubMed","id":"41606328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9UNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9UO2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---