9OTY

DDB1-CRBN with CK1 alpha, SB-405483, and DEG-47: composite map and model submission

This is a non-PDB format compatible entry.

Summary for 9OTY

• Entry DOI: 10.2210/pdb9oty/pdb
• EMDB information: 70862
• Descriptor: DNA damage-binding protein 1, Protein cereblon, Casein kinase I isoform alpha, ... (6 entities in total)
• Functional Keywords: e3 ligases, cullin ring ligase, crl4, cereblon, crbn, molecular glues, imids, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 172511.82

Authors

Rizvi, Z.,Lander, G.C. (deposition date: 2025-05-27, release date: 2025-11-19, Last modification date: 2025-12-24)

• Primary citation: Rizvi, Z.,Dippon, V.N.,Choudhry, A.E.,Chung, C.W.,Alkuraya, A.F.,Xu, W.,Tao, X.B.,Jurewicz, A.J.,Schneck, J.L.,Chen, W.,Curnutt, N.M.,Kabir, F.,Chan, K.H.,Queisser, M.A.,Musetti, C.,Dai, H.,Benowitz, A.B.,Woo, C.M.,Lander, G.C.; Identification of a cryptic allosteric site on the E3 ligase adapter protein cereblon; Nature, 2025; DOI: 10.1038/s41586-025-09994-w

Experimental method

ELECTRON MICROSCOPY (3 Å)