Summary for 9CUO
Entry DOI | 10.2210/pdb9cuo/pdb |
Descriptor | Protein cereblon, ZINC ION, (3S)-3-(3-methyl-2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)piperidine-2,6-dione, ... (6 entities in total) |
Functional Keywords | crbn, e3, protein degradation, ligase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 79190.35 |
Authors | Zheng, X.,Ji, N.,Campbell, V.,Slavin, A.,Zhu, X.,Chen, D.,Rong, H.,Enerson, B.,Mayo, M.,Sharma, K.,Browne, C.M.,Klaus, C.R.,Li, H.,Massa, G.,McDonald, A.A.,Shi, Y.,Sintchak, M.,Skouras, S.,Walther, D.M.,Yuan, K.,Zhang, Y.,Kelleher, J.,Guang, L.,Luo, X.,Mainolfi, N.,Weiss, M.M. (deposition date: 2024-07-26, release date: 2024-08-28) |
Primary citation | Zheng, X.,Ji, N.,Campbell, V.,Slavin, A.,Zhu, X.,Chen, D.,Rong, H.,Enerson, B.,Mayo, M.,Sharma, K.,Browne, C.M.,Klaus, C.R.,Li, H.,Massa, G.,McDonald, A.A.,Shi, Y.,Sintchak, M.,Skouras, S.,Walther, D.M.,Yuan, K.,Zhang, Y.,Kelleher, J.,Liu, G.,Luo, X.,Mainolfi, N.,Weiss, M.M. Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases. J.Med.Chem., 2024 Cited by PubMed: 39151120DOI: 10.1021/acs.jmedchem.4c01305 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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