9BK3
Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (R-enantiomer, orthorhombic P form)
This is a non-PDB format compatible entry.
Summary for 9BK3
Entry DOI | 10.2210/pdb9bk3/pdb |
Descriptor | L-lactate dehydrogenase A chain, CHLORIDE ION, MALONATE ION, ... (5 entities in total) |
Functional Keywords | lactate dehydrogenase, oxidoreductase, ldha, inhibitor complex, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 157370.06 |
Authors | Lovell, S.,Cooper, A.,Battaile, K.P.,Sharma, H. (deposition date: 2024-04-26, release date: 2024-07-10) |
Primary citation | Sharma, H.,Mondal, S.,Urquiza, U.,Esparza, C.,Bartlett, S.,Santa-Pinter, L.,Hill, H.,White, M.,Sharma, P.,Luckett-Chastain, L.,Cooper, A.,Rasel, M.,Gao, P.,Battaile, K.P.,Shukla, S.K.,Lovell, S.,Ihnat, M.A. Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer. Eur.J.Med.Chem., 275:116598-116598, 2024 Cited by PubMed: 38925013DOI: 10.1016/j.ejmech.2024.116598 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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