9BK3
Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (R-enantiomer, orthorhombic P form)
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | L-lactate dehydrogenase A chain | polymer | 352 | 39119.2 | 4 | UniProt (P00338) In PDB | Homo sapiens (human) | LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59 |
2 | A, C, D | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
3 | B, C, D | MALONATE ION | non-polymer | 102.0 | 3 | Chemie (MLI) | |||
4 | D | (2R)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid | non-polymer | 445.4 | 1 | Chemie (A1AR0) | |||
5 | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 331 (UniProt: P00338)
PDB | External Database | Details |
---|---|---|
Met -20 | - | initiating methionine |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
Ser -13 | - | expression tag |
Thr -12 | - | expression tag |
Ser -11 | - | expression tag |
Val -10 | - | expression tag |
Asp -9 | - | expression tag |
Leu -8 | - | expression tag |
Gly -7 | - | expression tag |
Thr -6 | - | expression tag |
Glu -5 | - | expression tag |
Asn -4 | - | expression tag |
Leu -3 | - | expression tag |
Tyr -2 | - | expression tag |
Phe -1 | - | expression tag |
Gln 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 156476.7 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 893.3 | |
All* | Total formula weight | 157370.1 |