9BBB

Human CYP3A4 bound to an inhibitor

This is a non-PDB format compatible entry.

Summary for 9BBB

• Entry DOI: 10.2210/pdb9bbb/pdb
• Descriptor: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, cobicistat, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 57150.32

Authors

Sevrioukova, I.F. (deposition date: 2024-04-05, release date: 2024-07-03)

• Primary citation: Sevrioukova, I.F.; Interaction of CYP3A4 with the inhibitor cobicistat: Structural and mechanistic insights and comparison with ritonavir; to be published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)