8ZSR

Complex I form respirasome open state bound by proguanil (SC-ProgO)

This is a non-PDB format compatible entry.

Summary for 8ZSR

• Entry DOI: 10.2210/pdb8zsr/pdb
• EMDB information: 60371 60372 60373 60374 60425
• Descriptor: NADH-ubiquinone oxidoreductase chain 4L, Acyl carrier protein, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial, ... (58 entities in total)
• Functional Keywords: metformin, electron transport chain, respirasome, mammalia, membrane protein
• Biological source: Sus scrofa (pig); More
• Total number of polymer chains: 45
• Total formula weight: 991306.67

Authors

Teng, F.,He, Z.X.,Hu, Y.Q.,Xu, C.Y.,Guo, R.Y.,Zhou, L. (deposition date: 2024-06-05, release date: 2025-12-17)

• Primary citation: Teng, F.,He, Z.X.,Yang, Y.Q.,Guo, R.Y.,Hu, Y.Q.,Xu, C.Y.,Zhou, R.H.,Zhang, X.,Zhang, S.,Zhou, L.; structural basis for inhibition of mammalian respirasome by metformin and proguanil; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.1 Å)