8ZQU

The crystal structure of PDE4D with isoaurostatin derivatives 2-6

This is a non-PDB format compatible entry.

Summary for 8ZQU

• Entry DOI: 10.2210/pdb8zqu/pdb
• Descriptor: 3',5'-cyclic-AMP phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 116472.95

Authors

Huang, Y.-Y.,Luo, H.-B. (deposition date: 2024-06-03, release date: 2025-02-12)

• Primary citation: Huang, Y.Y.,Luo, X.,Zhang, K.,Liang, Y.,Zhang, F.,Liao, G.,Xie, S.,Huang, P.L.,Hou, S.,Zhou, Q.,Zou, Y.,Luo, H.B.; Structure-based optimization of isoaurostatin as novel PDE4 inhibitors with anti-fibrotic effects; Chin.Chem.Lett., :110586-, 2024; DOI: 10.1016/j.cclet.2024.110586

Experimental method

X-RAY DIFFRACTION (2.00004554556 Å)