8ZQP

Human high-affinity choline transporter CHT1 bound to ML352 under NaCl condition, with sodium ion coordinated.

This is a non-PDB format compatible entry.

Summary for 8ZQP

• Entry DOI: 10.2210/pdb8zqp/pdb
• EMDB information: 60387
• Descriptor: High affinity choline transporter 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]-N-{[3-(propan-2-yl)-1,2-oxazol-5-yl]methyl}benzamide, ... (5 entities in total)
• Functional Keywords: transporter, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 64236.15

Authors

Qiu, Y.,Gao, Y.,Zhao, Y. (deposition date: 2024-06-03, release date: 2024-12-04)

• Primary citation: Qiu, Y.,Gao, Y.; Ion coupling and inhibitory mechanisms of the human presynaptic high-affinity choline transporter CHT1; Structure, 2024; DOI: 10.1016/j.str.2024.11.009

Experimental method

ELECTRON MICROSCOPY (3.1 Å)