8ZNC

Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH, AKG in the steady stage of reaction

8ZNC の概要

• エントリーDOI: 10.2210/pdb8znc/pdb
• 関連するPDBエントリー: 8ZMU
• EMDBエントリー: 60267
• 分子名称: Glutamate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-OXOGLUTARIC ACID, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, complex, nadph, 2-oxoglutarate, mutant
• 由来する生物種: Thermococcus profundus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47269.56

構造登録者

Wakabayashi, T.,Nakasako, M. (登録日: 2024-05-26, 公開日: 2024-06-12)

• 主引用文献: Wakabayashi, T.,Oide, M.,Matsui, Y.,Nakasako, M.; Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action; To Be Published,

実験手法