8ZMF
Crystal structure of an inverse agonist antipsychotic drug derivative-bound 5-HT2C
This is a non-PDB format compatible entry.
Summary for 8ZMF
Entry DOI | 10.2210/pdb8zmf/pdb |
Descriptor | 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 1-[(4-fluorophenyl)methyl]-1-[(8~{S})-5-methyl-5-azaspiro[2.5]octan-8-yl]-3-[[4-(2-methylpropoxy)phenyl]methyl]urea (2 entities in total) |
Functional Keywords | class a g protein-coupled receptor, inverse agonist, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 50223.93 |
Authors | Oguma, T.,Asada, H.,Sekiguchi, Y.,Imono, M.,Iwata, S.,Kusakabe, K. (deposition date: 2024-05-23, release date: 2024-08-28) |
Primary citation | Oguma, T.,Jino, K.,Nakahara, K.,Asada, H.,Fuchino, K.,Nagatani, K.,Kouki, K.,Okamoto, R.,Takai, N.,Koda, K.,Fujita, S.,Sekiguchi, Y.,Yasuo, K.,Mayumi, K.,Abe, A.,Imono, M.,Horiguchi, N.,Iwata, S.,Kusakabe, K.I. Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. J.Med.Chem., 2024 Cited by PubMed: 39137033DOI: 10.1021/acs.jmedchem.4c01244 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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