8ZM0
A self-assembled nanofiber
Summary for 8ZM0
| Entry DOI | 10.2210/pdb8zm0/pdb |
| EMDB information | 60234 |
| Descriptor | TYR-ALA-TRP-PHE (1 entity in total) |
| Functional Keywords | a chemically synthesized peptide that can be self-assembled into nanofiber, de novo protein |
| Biological source | synthetic construct |
| Total number of polymer chains | 62 |
| Total formula weight | 36310.30 |
| Authors | Shi, J.H.,Fang, Y.,Ma, D.,Wang, H.M. (deposition date: 2024-05-21, release date: 2025-05-21, Last modification date: 2025-12-24) |
| Primary citation | Fang, Y.,Shi, J.,Liang, J.,Ma, D.,Wang, H. Water-regulated viscosity-plasticity phase transitions in a peptide self-assembled muscle-like hydrogel. Nat Commun, 16:1058-1058, 2025 Cited by PubMed Abstract: The self-assembly of small molecules through non-covalent interactions is an emerging and promising strategy for building dynamic, stable, and large-scale structures. One remaining challenge is making the non-covalent interactions occur in the ideal positions to generate strength comparable to that of covalent bonds. This work shows that small molecule YAWF can self-assemble into a liquid-crystal hydrogel (LCH), the mechanical properties of which could be controlled by water. LCH can be used to construct stable solid threads with a length of over 1 meter by applying an external force on 2 µL of gel solution followed by water-regulated crystallization. These solid threads can support 250 times their weight. Cryogenic electron microscopy (Cryo-EM) analysis unravels the three-dimensional structure of the liquid-crystal fiber (elongated helix with C2 symmetry) at an atomic resolution. The multiscale mechanics of this material depend on the specificity of the molecular structure, and the water-controlled hierarchical and sophisticated self-assembly. PubMed: 39865087DOI: 10.1038/s41467-025-56415-7 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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