8ZFP

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and MRL24

Summary for 8ZFP

• Entry DOI: 10.2210/pdb8zfp/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, 2-chloro-5-nitro-N-phenylbenzamide, (2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID, ... (4 entities in total)
• Functional Keywords: nuclear receptors, tzds, drug design, therapeutic targets, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 64507.37

Authors

Shang, J.,Kojetin, D.J. (deposition date: 2024-05-08, release date: 2024-08-07)

• Primary citation: Shang, J.,Kojetin, D.J.; Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.; Elife, 2024; DOI: 10.7554/eLife.99782.1

Experimental method

X-RAY DIFFRACTION (2.48 Å)