8ZC5

SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, focused refinement of RBD region

Summary for 8ZC5

• Entry DOI: 10.2210/pdb8zc5/pdb
• EMDB information: 39923
• Descriptor: Spike protein S1, Light chain of D1F6 Fab, Heavy chain of D1F6 Fab, ... (4 entities in total)
• Functional Keywords: spike protein, antibody fab fragment, complex, viral protein/immune system, viral protein-immune system complex
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 6
• Total formula weight: 96297.58

Authors

Liu, B.,Gao, X.,Li, Z.,Chen, Q.,He, J.,Xiong, X. (deposition date: 2024-04-28, release date: 2024-05-15, Last modification date: 2024-06-12)

• Primary citation: Liu, B.,Niu, X.,Deng, Y.,Zhang, Z.,Wang, Y.,Gao, X.,Liang, H.,Li, Z.,Wang, Q.,Cheng, Y.,Chen, Q.,Huang, S.,Pan, Y.,Su, M.,Lin, X.,Niu, C.,Chen, Y.,Yang, W.,Zhang, Y.,Yan, Q.,He, J.,Zhao, J.,Chen, L.,Xiong, X.; An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike.; Cell Rep, 43:114265-114265, 2024; PubMed: 38805396; DOI: 10.1016/j.celrep.2024.114265

Experimental method

ELECTRON MICROSCOPY (3.91 Å)