8Z2V

Crystal structure of Sonic hedgehog in complex with antibody 5E1 mutant H-R102A with metals

Summary for 8Z2V

Entry DOI	10.2210/pdb8z2v/pdb
Descriptor	Sonic hedgehog protein N-product, Heavy chain of antibody 5E1, Light chain of antibody 5E1, ... (8 entities in total)
Functional Keywords	sonic hedgehog protein (shh), antibody, flexible/fluctuated epitope, affinity improvement, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	71636.53
Authors	Caaveiro, J.M.M.,Kaneda, I.,Tsumoto, K. (deposition date: 2024-04-13, release date: 2025-04-16)
Primary citation	Kaneda, I.,Matsunaga, R.,Nagatoishi, S.,Senoo, A.,Caaveiro, J.M.M.,Kuroda, D.,Tsumoto, K. Biophysical insights to improve affinity of antibodies to fluctuated epitope of antigen: A case of anti-Shh antibody 5E1 against Shh antigen. To Be Published,
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation