8YYZ

Crystal structure of Sonic hedgehog in complex with antibody 5E1 mutant H-R102A in the absence of metals

Summary for 8YYZ

• Entry DOI: 10.2210/pdb8yyz/pdb
• Descriptor: Sonic hedgehog protein N-product, Heavy chain antibody 5E1 mutated, Light chain antibody 5E1, ... (7 entities in total)
• Functional Keywords: sonic hedgehog protein (shh), antibody, flexible/fluctuated epitope, affinity improvement, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 71886.59

Authors

Caaveiro, J.M.M.,Senoo, A.,Kaneda, I.,Tsumoto, K. (deposition date: 2024-04-04, release date: 2025-04-09)

• Primary citation: Kaneda, I.,Matsunaga, R.,Nagatoishi, S.,Senoo, A.,Caaveiro, J.M.M.,Kuroda, D.,Tsumoto, K.; Biophysical insights to improve affinity of antibodies to fluctuated epitope of antigen: A case of anti-Shh antibody 5E1 against Shh antigen.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)