8YW5
Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex
Summary for 8YW5
Entry DOI | 10.2210/pdb8yw5/pdb |
EMDB information | 39623 |
Descriptor | Retatrutide, Glucagon receptor, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total) |
Functional Keywords | g protein-coupled receptor, ligand recognition, receptor activation, unimolecular agonist, retatrutide, structural protein |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 156902.22 |
Authors | Li, W.Z.,Zhou, Q.T.,Cong, Z.T.,Yuan, Q.N.,Li, W.X.,Zhao, F.H.,Xu, H.E.,Zhao, L.H.,Yang, D.H.,Wang, M.W. (deposition date: 2024-03-29, release date: 2024-08-07) |
Primary citation | Li, W.,Zhou, Q.,Cong, Z.,Yuan, Q.,Li, W.,Zhao, F.,Xu, H.E.,Zhao, L.H.,Yang, D.,Wang, M.W. Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10:77-77, 2024 Cited by PubMed: 39019866DOI: 10.1038/s41421-024-00700-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.84 Å) |
Structure validation
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