8YW4

Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex

8YW4 の概要

• エントリーDOI: 10.2210/pdb8yw4/pdb
• EMDBエントリー: 39622
• 分子名称: Mini-Gs, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: g protein-coupled receptor, ligand recognition, receptor activation, unimolecular agonist, retatrutide, structural protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 170814.92

構造登録者

Li, W.Z.,Zhou, Q.T.,Cong, Z.T.,Yuan, Q.N.,Li, W.X.,Zhao, F.H.,Xu, H.E.,Zhao, L.H.,Yang, D.H.,Wang, M.W. (登録日: 2024-03-29, 公開日: 2024-09-18, 最終更新日: 2025-07-02)

• 主引用文献: Li, W.,Zhou, Q.,Cong, Z.,Yuan, Q.,Li, W.,Zhao, F.,Xu, H.E.,Zhao, L.H.,Yang, D.,Wang, M.W.; Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.; Cell Discov, 10:77-77, 2024; PubMed: 39019866; DOI: 10.1038/s41421-024-00700-0

実験手法

ELECTRON MICROSCOPY (3.26 Å)