8YTD

Crystal Structure of TrkA D5 domain in complex with two different macrocyclic peptides

Summary for 8YTD

• Entry DOI: 10.2210/pdb8ytd/pdb
• Descriptor: High affinity nerve growth factor receptor, Macrocyclic Peptide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 15378.30

Authors

Yamada, T.,Mihara, K.,Ueda, T.,Yamauchi, D.,Shimizu, M.,Ando, A.,Mayumi, K.,Nakata, Z.,Mikamiyama, H. (deposition date: 2024-03-25, release date: 2024-07-10, Last modification date: 2024-07-24)

• Primary citation: Yamada, T.,Mihara, K.,Ueda, T.,Yamauchi, D.,Shimizu, M.,Ando, A.,Mayumi, K.,Nakata, Z.,Mikamiyama, H.; Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists.; J.Med.Chem., 67:11197-11208, 2024; PubMed: 38950284; DOI: 10.1021/acs.jmedchem.4c00715

Experimental method

X-RAY DIFFRACTION (2.34 Å)