8YRY

HER3 in complex with FAb Hu3f8

Summary for 8YRY

• Entry DOI: 10.2210/pdb8yry/pdb
• EMDB information: 39553
• Descriptor: Receptor tyrosine-protein kinase erbB-3, fab Hu3f8 heavy chain, fab Hu3f8 light chain (3 entities in total)
• Functional Keywords: cryo-em, her3-fab complex, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 62452.83

Authors

Wang, M.,Li, X. (deposition date: 2024-03-22, release date: 2025-06-25, Last modification date: 2026-01-07)

• Primary citation: Li, X.,Liang, L.,Zhu, Z.,Hua, H.,Qiu, Y.; DB-1310, a HER3-targeting antibody-drug conjugate, has synergistic anti-tumor activity with trastuzumab in HER2- and HER3-expressing breast cancer.; Cancer Biol Med, 22:231-236, 2025; PubMed: 40110648; DOI: 10.20892/j.issn.2095-3941.2024.0586

Experimental method

ELECTRON MICROSCOPY (2.93 Å)